Gene therapy is a medical technology in which DNA is directly used as a pharmaceutical substance. With this technique, the genes or fragments of these are inserted into the human body to prevent, treat, or treating a disease. Carrier’s non-viral or viral origin achieves the transfer of the gene Essay on the Importance and uses of Gene Therapy for Human! Gene therapy is the treatment of disease by replacing, altering, or supplementing a gene that is absent or abnormal and whose absence or abnormality is responsible for the disease. Gene therapy is unique in that it employs the genetic material, DNA, itself as the means of blogger.comted Reading Time: 7 mins Gene Therapy Essay. Words19 Pages. Gene Therapy. Gene therapy is a powerful new technology that has the ability to change the way medicine is practiced in the future. The potential of gene therapy offers great hope for cure and alleviation of suffering from genetic disorders that
FREE Gene therapy Essay
For over fifteen years, genes have been used to produce, with biotechnological techniques, pure proteins that are used as biopharmaceuticals insulin, growth hormone, blood coagulation factors, erythropoietin, etc.
Gene therapy is a medical technology in which DNA is directly used as a pharmaceutical substance. With this technique, gene therapy essay, the genes gene therapy essay fragments of these are inserted into the human body to prevent, treat, or treating a disease. The greatest difficulty encountered in transferring the gene is achieving a sufficient level of efficiency. Gene therapy can potentially cure many diseases, both genetic and acquired.
The experimental clinical gene therapy began in To date it around involving nearly 3, patients were made. Some of these trials have been conducted or are currently underway in Switzerland. However, the results obtained so far are strictly experimental. The term "somatic" is opposed to the term "germinal. Currently, it is impossible to completely control the genetic alterations that are brought about by a gene transfer. Consequently, there is the risk of provoking physiological anomalies that would be transmitted to subsequent generations; furthermore, the alteration of heritable genetic material raises a series of ethical and moral questions, gene therapy essay.
For these reasons, gene therapy essay, the genetic modification of germ cell lines is not considered an adaptable strategy, and its clinical trial is prohibited in Switzerland as in almost all other countries in the world. With gene transfer on somatic cell lines, the genome of tissues muscles, lungs, brain, bones, kidneys, heart, etc.
is changed, without this modification being passed on to the next generation; the genetic alteration concerns only the patient on whom it was made. This does not mean that such therapy is risk-free. We are studying the complications of random insertion of a foreign gene into the genome; according to the carrier that is used, gene therapy essay, the risks can be more or less high, gene therapy essay, thus determining the indications and contra-indications of a given treatment.
Lungs, brain, bones, kidneys, gene therapy essay, heart, etc. Theoretically, all diseases can be treated through gene expression interventions. Commonly, gene therapy is thought to help heal hereditary diseases such as:. In reality, this therapy can also treat diseases that gene therapy essay those genetically predisposed, but which depend heavily on environmental factors, such as:.
In vivo, physical methods have limited applicability to the transfer of genes to surface tissues, while they are more conveniently used for ex vivo transfer. Direct injection into the tissues is effective only when therapy does not require a large amount of expression of the transferred gene for example, when patients are treated with expression vectors for VEGF, growth factor of vascular endothelium.
The advantage of chemical methods is the ability to build the desired vector by combining the different chemical compounds, which are easily obtainable; however, the efficiency is to 1, times lower than that of biological vectors. Future improvements of this method, such as the creation of compounds formed by chemical and biological substances, gene therapy essay lead to the formation of "virosomes" or "artificial viruses.
In fact, these vectors can be designed to accumulate in the desired body compartments, due to surface molecules that are specific ligands. In biochemical methods, DNA is conjugated with proteins that can enter cells by endocytosis, for example, through internalization mediated by a receptor.
These methods offer the advantage of gene therapy essay targeting certain cells, and such specificity is not possible with chemical methods.
Most of these viruses are constructed in such a way that they can only replicate in genetically manipulated cells. The major advantage these gene therapy essay offer is that they can transport genes with very high efficiency.
Some vectors for example, lentivirus allow the integration of the introduced gene into the host cell genome. In this way, the expression of the introduced gene is permanent. The main risk we face is that the virus gives rise to particles capable of reproducing in an uncontrolled way. However, the use of modern protocols appears to have significantly reduced this risk. Some vectors for example, recombinant adenoviruses transport toxic components such as capsid proteins into the cell; this may preclude their use for non-serious diseases.
Finally, vectors such as AAV do not allow the packaging of genes with a long DNA sequence, causing a severe limitation for the treatment of diseases such as muscular dystrophy and cystic fibrosis, where the gene of interest is larger than the space available in vector. Many studies and experiments are conducted to make recombinant viruses capable of attaching to specific surfaces within the body to allow a systemic tissue-specific gene transfer.
They are causing a serious limitation for the treatment of diseases such as muscular dystrophy and cystic fibrosis, where the gene of interest is larger than the space available in the vector. Currently, many studies and experiments are conducted with the aim of making recombinant viruses capable of attaching to specific surfaces within the body, so as to allow a systemic tissue-specific gene transfer.
Currently, many studies and experiments are conducted with the aim of making recombinant viruses capable of attaching to specific surfaces within the bodyto allow a systemic tissue-specific gene transfer. search order now. Need a custom essay? Login with Facebook. What is gene therapy? What does 'somatic' gene therapy mean? What diseases can be treated with gene therapy? Commonly, gene therapy is gene therapy essay to help heal hereditary diseases such as: - muscular dystrophy - cystic fibrosis - hemophilia - type I diabetes - metabolic diseases phenylketonuria - Physiological anomalies mucopolysaccharidosis, Gaucher syndrome, etc.
In reality, this therapy can also treat diseases that affect those genetically predisposed, but which depend heavily on environmental factors, such as: - cancer - cardiovascular diseases - Neurodegenerative diseases Alzheimer's disease, Parkinson's disease, etc.
Finally, gene therapy can also treat acquired diseases such as: gene therapy essay Various types of trauma bone fractures, wounds, burns - Ischemias tissue necrosis caused by an interruption of blood supply - Infections Which gene transfer vectors are used today?
What is "in vivo" and "ex vivo? Physical methods - hydrodynamic pressure. We will write it for you. Order now. All you need to know about Neuroendocrinology, gene therapy essay. All you need to know about Big data management. All you need to know about digital special effects. All you need to know Technical Writing? Basics the Game Theory in Cryptoeconomics. Business innovation ideas for making money.
Biosensors for cancer diagnosis. Business Analysis: Pricing strategies and Demand Curve. Cognitive Computing- How does Cognitive Computing work? Consciousness: characteristics and peculiarities, gene therapy essay. Conservation Economics. Cybersecurity in business: challenges, risks, and practices. Demographic trends and how they affect Economic Growth. Dance as an art form and entertainment.
Discrimination Economics. Gene therapy essay of Wages. Everything you need to know about short-term memory. Economic and Policy Impacts of Demographics. Ethics: an essay on the understanding of evil. Emotions: what are they? Theories explained, gene therapy essay. Factors of Demographic Data Collection. Factors Affecting Purchasing Behavior. Financial Statement Analysis. Factors Influencing Interest and Exchange Rates. Government's Intervention in The Labor Market.
Guide on the Pathways of the nervous system. Game theory in microeconomics. Globalization: definition, causes, social impact and risks. How Relativism Promotes Pluralism and Tolerance. History of silent cinema. How news report can be strengthened through multimedia.
Introduction to Population Problems. Imperfect Information and Asymmetric Information. Imperfect Information in Insurance. Introduction to Labor Markets, gene therapy essay. Journalism: What is News? Journalism: Broadcast media and Television Presenters. Journalism: Sources of News. Journalism and Law. Key Determinants of National Income. Key Factors That Affect Pricing Decisions. Kinetic models in biology and Related fields.
Know about the different forms of traditional African dances, gene therapy essay. Latest technology trends. Latest dance trends.
Cell and Gene Therapy Solutions: Enabling PSC Translation Workflows
, time: 1:05:15A SUMMARY OF GENE THERAPY Example | Graduateway
Mar 04, · Essay on Gene Therapy! Essay on the History of Gene Therapy: Gene therapy was conceived in , the breakthrough was the synthesis of recombinant DNA molecule (rDNA) in The rDNA molecules were first duplicated and grown in bacteria in Later split gene was discovered through the use of recombinant DNA technologies in Estimated Reading Time: 10 mins Jun 19, · Gene Therapy is the process of replacing a defective gene inside a patient’s DNA with a working gene that will produce the correct gene products. The genetic diseases “in which a single known gene does not function properly”, such as sickle cell anaemia, thalassaemia and Lesch-Nyhan syndrome, are most suitable to be treated with the gene blogger.comted Reading Time: 3 mins Gene therapy is a medical technology in which DNA is directly used as a pharmaceutical substance. With this technique, the genes or fragments of these are inserted into the human body to prevent, treat, or treating a disease. Carrier’s non-viral or viral origin achieves the transfer of the gene
No comments:
Post a Comment